Author:

Keywords:

Science & Technology, Physical Sciences, Chemistry, Analytical, Chemistry, ELECTROKINETIC CHROMATOGRAPHY, LIQUID-CHROMATOGRAPHY, ZONE ELECTROPHORESIS, ISOMERS, Anti-Inflammatory Agents, Non-Steroidal, Cephalosporins, Coumarins, Electrolytes, Electrophoresis, Glucose, Oligosaccharides, Polysaccharides, Stereoisomerism, Ultrafiltration, 03 Chemical Sciences, 09 Engineering, 10 Technology, Analytical Chemistry, 34 Chemical sciences, 40 Engineering

Abstract:

Maltodextrins, i.e., mixtures of linear alpha-(1-4)-linked D-glucose polymers, were found to be effective as chiral electrolyte modifiers to perform direct, rapid separations by capillary electrophoresis of racemic mixtures of 2-arylpropionic acid non-steroidal anti-inflammatory compounds and coumarinic anticoagulant drugs, and also diastereomeric cephalosporin antibiotics. Enantioselectivity seemed to be dependent on an as yet unidentified combination of variables.