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Journal Of Organic Chemistry

Publication date: 2008-08-01
Volume: 73 Pages: 6003 - 6005
Publisher: American Chemical Society

Author:

Lavandera, Ivan
Kern, Alexander ; Ferreira-Silva, Bianca ; Glieder, Anton ; de Wildeman, Stefaan ; Kroutil, Wolfgang

Keywords:

Science & Technology, Physical Sciences, Chemistry, Organic, Chemistry, BROAD SUBSTRATE-SPECIFICITY, ALCOHOL-DEHYDROGENASE, ENANTIOSELECTIVE REDUCTION, CARBONYL REDUCTASE, ASYMMETRIC REDUCTION, CHIRAL ALCOHOLS, OXIDATION, SYSTEM, TOOL, Alcohol Dehydrogenase, Catalysis, Escherichia coli, Ketones, Molecular Structure, Oxidation-Reduction, Ralstonia, Substrate Specificity, ras Proteins, 0304 Medicinal and Biomolecular Chemistry, 0305 Organic Chemistry, Organic Chemistry, 3404 Medicinal and biomolecular chemistry, 3405 Organic chemistry

Abstract:

Ketones with two bulky substituents, named bulky-bulky ketones, as well as less sterically demanding ketones were successfully reduced to the corresponding optically highly enriched alcohols using a novel identified recombinant short-chain alcohol dehydrogenase RasADH from Ralstonia sp. DSM 6428 overexpressed in E. coli.