Author:

Abstract:

This project aspires 1. to demonstrate cancer cells dual addiction to anti-apoptotic Bcl-2 by exploiting the properties of BH3 mimetics and BH4-targeting tools 2. to screen and/or develop novel, in vivo applicable petidomimetics and TAT-IDPs peptide derivatives targeting Bcl-2 via its BH4-domain via a Celltox-TM Green Cytotoxicity Assay 3. to establish the effect of TAT-IDPs and derivatives on the survival and function of platelets from healthy volunteers and cancer patients.