Seminars in Diagnostic Pathology

Publication date: 2011-08
Volume: 28 Pages: 190 - 201
ISSN: 0740-2570, 1930-1111 PMID: 21850985
DOI: 10.1053/j.semdp.2011.03.002
Publisher: Grune & Stratton


Inghirami, Giorgio
Pileri, Stefano A ; European T-Cell Lymphoma Study Group,


Humans, Lymphoma, Large-Cell, Anaplastic, European T-Cell Lymphoma Study Group, Pathology, 1103 Clinical Sciences


The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated.