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PLoS One

Publication date: 2012-01
ISSN: 1932-6203 PMID: 22666420
DOI: 10.1371/journal.pone.0037943
Publisher: Public Library of Sciene

Author:

Bertucci, François
Lagarde, Arnaud ; Ferrari, Anthony ; Finetti, Pascal ; Charafe-Jauffret, Emmanuelle ; Van Laere, Steven ; Adelaide, José ; Viens, Patrice ; Thomas, Gilles ; Birnbaum, Daniel ; Olschwang, Sylviane

Keywords:

Alleles, Chromosomes, Human, Pair 8, Colorectal Neoplasms, Gene Frequency, Genetic Predisposition to Disease, Humans, Inflammatory Breast Neoplasms, Neoplasm Metastasis, Polymorphism, Single Nucleotide, Prognosis, Survival Analysis, Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, LONG-RANGE INTERACTION, COLORECTAL-CANCER, PROSTATE-CANCER, MYC, EXPRESSION, RS6983267, VARIANT, LOCI, General Science & Technology

Abstract:

Association studies have identified low penetrance alleles that participate to the risk of cancer development. The 8q24 chromosomal region contains several such loci involved in various cancers that have been recently studied for their propensity to influence the clinical outcome of prostate cancer. We investigated here two 8q24 breast and colon cancer risk alleles in the close vicinity of the MYC gene for their role in the occurrence of distant metastases.