Journal of Urology

Publication date: 2010-08
Volume: 184 Pages: 459 - 63
ISSN: 0022-5347, 1527-3792 PMID: 20620398
DOI: 10.1016/j.juro.2010.03.131
Publisher: Elsevier Science Inc.

Author:

Owen, Helen
Giedl, J ; Wild, Peter J ; Fine, Samson W ; Humphrey, Peter A ; Dehner, Louis P ; Amin, Mahul B ; Epstein, Johnathan I ; Blaszyk, H ; Hughes, David ; Hartmann, Arndt ; Stoehr, Robert ; Catto, James W

Keywords:

Adolescent, Adult, Age Factors, Aged, Carcinoma, Transitional Cell, Epigenesis, Genetic, Female, Humans, Male, Middle Aged, Urinary Bladder Neoplasms, Young Adult, Urology & Nephrology, 1103 Clinical Sciences

Abstract:

Bladder urothelial cell carcinoma is uncommon in young patients. We recently reported a series of tumors in patients younger than 20 years at diagnosis and performed exhaustive genetic screening for molecular alterations. Few events typical of bladder urothelial cell carcinoma were detected. Since many carcinogenic events occur at the epigenetic rather than the genetic level, we analyzed the same tumors for alterations in DNA hypermethylation. We compared our findings with those in tumors in older patients with similar pathological profiles.