Journal of Affective Disorders

Publication date: 2007-01
Volume: 103 Pages: 113 - 120
ISSN: 0165-0327, 1573-2517 PMID: 17292480
DOI: 10.1016/j.jad.2007.01.015
Publisher: Elsevier


Scott, KM
Bruffaerts, Ronny ; Tsang, A ; Ormel, J ; Alonso, J ; Angermeyer, MC ; Benjet, C ; Bromet, E ; de Girolamo, G ; de Graaf, R ; Gasquet, I ; Gureje, O ; Haro, JM ; He, Y ; Kessler, RC ; Levinson, D ; Mneimneh, ZN ; Oakley Browne, MA ; Posada-Villa, J ; Stein, DJ ; Takeshima, T ; Von Korff, M


Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Psychiatry, Neurosciences & Neurology, anxiety, depression, cross-sectional, chronic conditions, GENERAL-POPULATION, SUBSTANCE USE, DISORDERS, COMORBIDITY, MORTALITY, SYMPTOMS, ORGANIZATION, PREVALENCE, DISEASE, IMPACT, Adult, Aged, Anxiety Disorders, Chronic Disease, Comorbidity, Cross-Cultural Comparison, Cross-Sectional Studies, Depressive Disorder, Major, Dysthymic Disorder, Female, Health Surveys, Humans, Male, Middle Aged, Sick Role, 11 Medical and Health Sciences, 17 Psychology and Cognitive Sciences


BACKGROUND: Prior research on the association between affective disorders and physical conditions has been carried out in developed countries, usually in clinical populations, on a limited range of mental disorders and physical conditions, and has seldom taken into account the comorbidity between depressive and anxiety disorders. METHODS: Eighteen general population surveys were carried out among adults in 17 countries as part of the World Mental Health Surveys initiative (N=42, 249). DSM-IV depressive and anxiety disorders were assessed using face-to-face interviews with the Composite International Diagnostic Interview (CIDI 3.0). Chronic physical conditions were ascertained via a standard checklist. The relationship between mental disorders and physical conditions was assessed by considering depressive and anxiety disorders independently (depression without anxiety; anxiety without depression) and conjointly (depression plus anxiety). RESULTS: All physical conditions were significantly associated with depressive and/or anxiety disorders but there was variation in the strength of association (ORs 1.2-4.5). Non-comorbid depressive and anxiety disorders were associated in equal degree with physical conditions. Comorbid depressive-anxiety disorder was more strongly associated with several physical conditions than were single mental disorders. LIMITATIONS: Physical conditions were ascertained via self report, though for a number of conditions this was self-report of diagnosis by a physician. CONCLUSIONS: Given the prevalence and clinical consequences of the co-occurrence of mental and physical disorders, attention to their comorbidity should remain a clinical and research priority.