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Journals of Gerontology A, Biological Sciences and Medical Sciences

Publication date: 2011-06
Volume: 66 Pages: 620 - 626
ISSN: 1079-5006, 1758-535X PMID: 21382886
DOI: 10.1093/gerona/glr025
Publisher: Gerontological Society of America

Author:

Ratkevicius, A
Joyson, A ; Selmer, I ; Dhanani, T ; Grierson, C ; Tommasi, AM ; de Vries, Annick ; Rauchhaus, P ; Crowther, D ; Alesci, S ; Yaworsky, P ; Gilbert, F ; Redpath, TW ; Brady, J ; Fearon, KCH ; Reid, DM ; Greig, CA ; Wackerhage, H

Keywords:

Adult, Aged, Follistatin, Follistatin-Related Proteins, Humans, Insulin-Like Growth Factor I, Interleukin-6, Male, Muscle Contraction, Myostatin, Proteins, Sarcopenia, Testosterone, Gerontology, 1103 Clinical Sciences

Abstract:

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm(2)) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm(2)) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm(2)), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < / .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.