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Psychological medicine

Publication date: 2008-11
Volume: 38 Pages: 1639 - 50
ISSN: 0033-2917, 1469-8978 PMID: 18298879
DOI: 10.1017/S0033291707002474
Publisher: Cambridge University Press (CUP)


Zhang, M
Lin, EHB ; Bruffaerts, Ronny ; Posada-Villa, J ; Angermeyer, MC ; Levinson, D ; de Girolamo, G ; Uda, H ; Mneimneh, Z ; Benjet, C ; Graaf, R de ; Scott, KM ; Gureje, O ; Seedat, S ; Haro, JM ; Bromet, EJ ; Alonso, J ; von Korff, M ; Kessler, R


Social Sciences, Science & Technology, Life Sciences & Biomedicine, Psychology, Clinical, Psychiatry, Psychology, Arthritis, mental disorders, cross-sectional, NATIONAL COMORBIDITY SURVEY, DIAGNOSTIC INTERVIEW CIDI, MUSCULOSKELETAL CONDITIONS, RHEUMATOID-ARTHRITIS, KNEE OSTEOARTHRITIS, OLDER-ADULTS, UNITED-STATES, RISK-FACTOR, DEPRESSION, PREVALENCE, Adult, Alcoholism, Anxiety Disorders, Cetrimonium Compounds, Comorbidity, Cross-Cultural Comparison, Drug Combinations, Female, Health Surveys, Humans, Male, Middle Aged, Mood Disorders, Myristates, Nicotinic Acids, Odds Ratio, Simethicone, Stearic Acids, 1701 Psychology, 1117 Public Health and Health Services, 1109 Neurosciences


BACKGROUND: Prior studies in the USA have reported higher rates of mental disorders among persons with arthritis but no cross-national studies have been conducted. In this study the prevalence of specific mental disorders among persons with arthritis was estimated and their association with arthritis across diverse countries assessed.MethodThe study was a series of cross-sectional population sample surveys. Eighteen population surveys of household-residing adults were carried out in 17 countries in different regions of the world. Most were carried out between 2001 and 2002, but others were completed as late as 2007. Mental disorders were assessed with the World Health Organization (WHO) World Mental Health-Composite International Diagnostic Interview (WMH-CIDI). Arthritis was ascertained by self-report. The association of anxiety disorders, mood disorders and alcohol use disorders with arthritis was assessed, controlling for age and sex. Prevalence rates for specific mental disorders among persons with and without arthritis were calculated and odds ratios (ORs) with 95% confidence intervals were used to estimate the association. RESULTS: After adjusting for age and sex, specific mood and anxiety disorders occurred among persons with arthritis at higher rates than among persons without arthritis. Alcohol abuse/dependence showed a weaker and less consistent association with arthritis. The pooled estimates of the age- and sex-adjusted ORs were about 1.9 for mood disorders and for anxiety disorders and about 1.5 for alcohol abuse/dependence among persons with versus without arthritis. The pattern of association between specific mood and anxiety disorders and arthritis was similar across countries. CONCLUSIONS: Mood and anxiety disorders occur with greater frequency among persons with arthritis than those without arthritis across diverse countries. The strength of association of specific mood and anxiety disorders with arthritis was generally consistent across disorders and across countries.