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PLoS One

Publication date: 2013-03
Pages: e58297 -
ISSN: 1932-6203 PMID: 23505482
DOI: 10.1371/journal.pone.0058297
Publisher: Public Library of Sciene

Author:

Castillo Cano, Virginia
Chiti, Fabrizio ; Ventura, Salvador

Keywords:

Amyloid, Carrier Proteins, Fungal Proteins, Hydrogen-Ion Concentration, Kinetics, Models, Molecular, Peptides, Protein Binding, Protein Folding, Protein Interaction Domains and Motifs, Protein Stability, Protein Structure, Secondary, Proteolysis, Solubility, Thermodynamics, General Science & Technology

Abstract:

Protein aggregation is linked to the onset of an increasing number of human nonneuropathic (either localized or systemic) and neurodegenerative disorders. In particular, misfolding of native α-helical structures and their self-assembly into nonnative intermolecular β-sheets has been proposed to trigger amyloid fibril formation in Alzheimer's and Parkinson's diseases.