Drug Discovery Today. Disease Models

Publication date: 2009-01
Pages: 41 - 45
ISSN: 1740-6757 PMID: 20407588
DOI: 10.1016/j.ddmod.2009.03.008
Publisher: Elsevier

Author:

Van Belle, Tom
Taylor, P ; von Herrath, MG

Keywords:

Neurology & Neurosurgery, 1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences

Abstract:

Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researchers to zoom in on specific aspects of this complex disease. In this review, we provide an overview of currently available mouse models for T1D.